| Identification | Back Directory | [Name]
VU 0364439 | [CAS]
1246086-78-1 | [Synonyms]
CS-629
VU 0364439
VU 0364439 10MG
VU 0364439, >=98%
VU0364439/VU-0364439
VU 0364439 USP/EP/BP
VU 0364439;VU0364439; VU-0364439
N-(3-Chloro-4-(N-(2-chlorophenyl)sulfamoyl)phenyl)picolinamide
N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide
2-PyridinecarboxaMide, N-[3-chloro-4-[[(2-chlorophenyl)aMino]sulfonyl]phenyl]-
N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide VU0364439 | [Molecular Formula]
C18H13Cl2N3O3S | [MDL Number]
MFCD22378484 | [MOL File]
1246086-78-1.mol | [Molecular Weight]
422.285 |
| Chemical Properties | Back Directory | [density ]
1.538±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥21.11 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O | [form ]
solid | [pka]
7.71±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) (1,2). | [storage]
Store at -20°C | [References]
[1]. lucyna pomierny-chamio?o, kinga rup, bartosz pomierny, et al. metabotropic glutamatergic receptors and their ligands in drug addiction. pharmacology & therapeutics, 2014, 142:281-305.
[2]. albert j. robichaud, darren w. engers, craig w. lindsley, et al. recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as cns therapeutics. acs chemical neuroscience, 2011, 2:433-449.
[3]. colleen m. niswender, kari a. johnson, c. david weaver, et al. discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. mol. pharmacol., 2008, 74(5):1345-1358.
[4]. darren w. engers, patrick r. gentry, richard williams, et al. synthesis and sar of novel, 4-(phenylsulfamoyl)phenylacetamide mglu4 positive allosteric modulators (pams) identified by functional high-throughput screening (hts). bioorg. med. chem. lett., 2010, 20:5175-5178. |
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