| Identification | Back Directory | [Name]
Incadronic | [CAS]
124351-85-5 | [Synonyms]
Incadronic
((Cycloheptylamino)methylene)diphosphonic acid
((cycloheptylamino)methylene)bis(phosphonic acid)
[(cycloheptylamino)-phosphonomethyl]phosphonic acid
Phosphonic acid, P,P'-[(cycloheptylamino)methylene]bis- | [Molecular Formula]
C8H19NO6P2 | [MOL File]
124351-85-5.mol | [Molecular Weight]
287.19 |
| Hazard Information | Back Directory | [Description]
Bisphonal, a new third generation drug, was launched in Japan for the
treatment of osteoporosis. It can be prepared in two steps by heating
cycloheptylamine, triethylorthoformate and diethyl phosphite followed by ester
hydrolysis. The mechanism of action is not well understood. Bisphonal has no effect
on bone mineralization but tightly binds to calcified bone matrix and inhibits bone
resorption. It causes a decrease in the number and activity of osteoclasts
(morphology and decrease in H+ secretion). They seem to undergo cell death with an
impairment in the process of osteoclast formation. Bisphonal does not induce
osteomalacia and its activity is partly mediated through osteoblasts (releases an
inhibitor of osteoclast recruitment). It is a potent inhibitor of squalene synthase (50-fold) maybe by Mg2+ chelation or as a pyrophosphate mimic, undergoes practically no
metabolism, and stimulates renal production of 1,25-dihydroxyvitamin D. | [Originator]
Yamanouchi (Japan) | [Uses]
Incandronate is a bisphosphonate derivative. Bisphosphonates are most widely used as agents for treating osteoporosis and have also been used for other purposes such as herbicides, anticancer agents, and antiparasitics. | [Definition]
ChEBI:Incadronic acid is a 1,1-bis(phosphonic acid). | [Brand name]
Bisphonal |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
|
| Tel: |
4008-099-669 |
| Website: |
http://www.approvedhomemanagement.com/ShowSupplierProductsList112975/0.htm |
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