天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->124083-20-1

124083-20-1

124083-20-1 Structure

124083-20-1 Structure
IdentificationBack Directory
[Name]

R-(+)-ETOMOXIR
[CAS]

124083-20-1
[Synonyms]

S-(+)-ETOMOXIR
R-(+)-ETOMOXIR
ethyl (2S)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate
(R)-2-[6-(4-CHLOROPHENOXY)HEXYL]OXIRANECARBOXYLIC ACID, ETHYL ESTER
(S)-2-[6-(4-CHLOROPHENOXY)HEXYL]OXIRANECARBOXYLIC ACID, ETHYL ESTER
(R)-2-[6-(4-Chlorophenoxy)hexyl]oxirane-2-carboxylic acid ethyl ester
(2R)-2-[6-(4-Chlorophenoxy)hexyl]-2-oxiranecarboxylic acid ethyl ester
(2S)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylic acid ethyl ester
2-Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-
2-Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-(R)-(+)-Etomoxir
[EINECS(EC#)]

200-258-5
[Molecular Formula]

C17H23ClO4
[MDL Number]

MFCD04039542
[MOL File]

124083-20-1.mol
[Molecular Weight]

326.82
Chemical PropertiesBack Directory
[Appearance]

Colourless Oil
[Melting point ]

32-34°C
[Boiling point ]

405.0±25.0 °C(Predicted)
[density ]

1.163
[storage temp. ]

Refrigerator
[solubility ]

≥32.7 mg/mL in DMSO; ≥109.6 mg/mL in EtOH; ≥48.3 mg/mL in H2O with gentle warming
[form ]

Powder
[color ]

Colorless to light yellow
[InChI]

InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1
[InChIKey]

DZLOHEOHWICNIL-QGZVFWFLSA-N
[SMILES]

O1C[C@]1(CCCCCCOC1=CC=C(Cl)C=C1)C(OCC)=O
Hazard InformationBack Directory
[Chemical Properties]

Colourless Oil
[Uses]

An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug
[Definition]

ChEBI: (2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid ethyl ester is an aromatic ether.
[Biological Activity]

etomoxir is a cell-permeable, irreversible, and stereospecific compound. etomoxir is shown to inhibit carnitine palmitoyltransferase (cpt)-1 and dgat activity in the mitochondria of rat heart h9c2 myoblastic cells at a concentration of 1-80 μm and 40 μm, respectively.
[Mechanism of action]

R-(+)-Etomoxir (ETO) is a carnitine palmitoyltransferase 1 (CPT1) inhibitor. ETO inhibits oxidative phosphorylation (OxPhos), a mitochondrial electron transport chain (ETC) that generates large amounts of ATP in cells. ETO prevents acylcarnitine formation. It is a step necessary for the translocation of fatty acyl chains from the cytoplasmic lysate to the mitochondrial intermembrane space. This step is essential for the production of ATP from fatty acid oxidation.
[storage]

Store at -20°C, protect from light, stored under nitrogen
Questions And AnswerBack Directory
[Description]

Etomoxir, or 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane.This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPARα. An off-target effect has been demonstrated at high concentrations of etomoxir on Coenzyme-A (CoA) metabolism.
[Application]

Etomoxir (R-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
Spectrum DetailBack Directory
[Spectrum Detail]

R-(+)-ETOMOXIR(124083-20-1)1HNMR
124083-20-1 suppliers list
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel: +8613720134139 , +8613720134139
Website: http://www.jknbiochem.com/
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: +8615858145714 , +8615858145714
Website: www.fandachem.com/
Company Name: Biochempartner
Tel: 0086-13720134139
Website: www.biochempartner.com
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Hubei Ipure Biology Co., Ltd
Tel: +8613367258412 , +8613367258412
Website: www.ipurechemical.com
Company Name: HONG KONG IPURE BIOLOGY CO.,LIMITED
Tel: 86 18062405514 18062405514 , 18062405514
Website: www.approvedhomemanagement.com/ShowSupplierProductsList1523002/0_EN.htm
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226 , 13588875226
Website: www.hzclap.com/en
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: https://www.dideu.com
Company Name: Baoji Guokang Bio-Technology Co., Ltd.
Tel: 0917-3909592 13892490616 , 13892490616
Website: http://www.gk-bio.com
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525 , +8618327326525
Website: topule.com/
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
Tel: +undefined18621343501 , +undefined18621343501
Website: www.acmec.com.cn/
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel: +8613817748580 , +8613817748580
Website: www.kean-chem.com
Company Name: Guangzhou CATO Research Chemicals Inc.
Tel: +86-020-81960175-617 +8615602392859 , +8615602392859
Website: www.cato-chem.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Tags:124083-20-1 Related Product Information
828934-41-4