| Identification | Back Directory | [Name]
2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- | [CAS]
1235318-89-4 | [Synonyms]
ADX88178
ADX-88178
ADX88178, >98%
ADX-88178;ADX 88178;ADX88178
5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine
4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-2-Pyrimidinamine
2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine | [Molecular Formula]
C12H12N6S | [MDL Number]
MFCD21340285 | [MOL File]
1235318-89-4.mol | [Molecular Weight]
272.33 |
| Hazard Information | Back Directory | [Description]
ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy. | [target]
ADX88178 is a metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4. |
|
| Company Name: |
Zhengzhou Alfachem Co.,Ltd.
|
| Tel: |
0371-53778726 18003825608 |
| Website: |
http://www.approvedhomemanagement.com/Supplier/10838232/ |
|