| Identification | Back Directory | [Name]
CAY10638 | [CAS]
1221413-57-5 | [Synonyms]
CAY10638
CAY10638 Exclusive
2,4-Thiazolidinedione, 5-[[4-[2-(2-thienyl)ethoxy]phenyl]methylene]- | [Molecular Formula]
C16H13NO3S2 | [MDL Number]
MFCD18382124 | [MOL File]
1221413-57-5.mol | [Molecular Weight]
331.41 |
| Hazard Information | Back Directory | [Description]
Prostaglandins have a short life in vivo because NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity.1 Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity.2,3 CAY10638 is a TZD derivative that inhibits 15-PGDH activity with an IC50 value of 31 nM.3 | [Definition]
ChEBI: CAY10638 is an aromatic ether. | [References]
1. Hansen, H.S. 15-Hydroxyprostaglandin dehydrogenase. A review Prostaglandins 12(4),647-679(1976).
2. Owens, D.R. Thiazolidinediones. An pharmacological overview Clin. Drug Investig. 22(8),485-505(2002).
3. Wu, Y., Tai, H.H., and Cho, H. Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors Bioorg. Med. Chem. 18,1428-1433(2010). |
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