| Identification | Back Directory | [Synonyms]
Propargyl-PEG4-NHBoc
Boc-N-Amido-PEG4-Alkyne
t-Boc-N-Amido-PEG4-propargyl
tert-butyl (3，6，9，12-tetraoxapentadec-14-yn-1-yl)carbamate
tert-butylN-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)carbamate | [MOL File]
1219810-90-8.mol |
| Chemical Properties | Back Directory | [Boiling point ]
426.0±40.0 °C(Predicted) | [density ]
1.054±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [pka]
12.23±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
t-Boc-N-Amido-PEG4-propargyl is a propargyl linker with one side protected by Boc group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The Boc protected amine can be deprotected under mild acidic conditions. | [Uses]
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-N-Amido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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