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ChemicalBook--->CAS DataBase List--->1217766-70-5

1217766-70-5

1217766-70-5 Structure

1217766-70-5 Structure
IdentificationBack Directory
[Name]

2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
[CAS]

1217766-70-5
[Synonyms]

[2H3]-Ketoconazole
2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
Ketoconazole D3Q: What is Ketoconazole D3 Q: What is the CAS Number of Ketoconazole D3 Q: What is the storage condition of Ketoconazole D3 Q: What are the applications of Ketoconazole D3
[Molecular Formula]

C26H28Cl2N4O4
[MOL File]

1217766-70-5.mol
[Molecular Weight]

531.43
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Chloroform: slightly soluble; Methanol: slightly soluble
[form ]

A solid
Safety DataBack Directory
[Symbol(GHS) ]


GHS06,GHS08,GHS09
[Signal word ]

Danger
[Hazard statements ]

H301-H360-H373-H400-H410
[Precautionary statements ]

P201-P202-P260-P264-P270-P273-P280-P301+P310-P321-P330-P308+P313-P314-P391-P405-P501
Hazard InformationBack Directory
[Description]

Ketoconazole-d3 is intended for use as an internal standard for the quantification of ketoconazole by GC- or LC-MS. Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 μg/ml).1 It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase, which arrests ergosterol biosynthesis at the fungal membrane. Ketoconazole also inhibits human CYP3A4 (IC50 = 0.54 μM). Formulations containing ketoconazole have been used in the treatment of fungal infections.
[Uses]

Ketoconazole-d3 is the labeled analogue of Ketoconazole (K186000), which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.
[storage]

Store at -20°C
[References]

1. Dilmaghanian, S., Gerber, J.G., Filler, D.G., et al. Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates Chirality 16(2),79-85(2004).
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