| Identification | Back Directory | [Name]
ATTAPULGITE | [CAS]
12174-11-7 | [Synonyms]
x250
zeogel
DILUEX
rvm-fg
Attagel
Attaclay
attasorb
Permagel
attapulg
attacote
attagel40
attagel50
attagel150
200u/p-rvm
palygorskit
min-u-gelfg
ATTAPULGITE
Attagpulgite
polygorskite
palygorscite
min-u-gel200
min-u-gel400
Palygorskite
attaclayx250
Attapulgitee
FULLERS EARTH
Mallina Attapulgite
activatedattapulgite
pharmasorb-colloidal
ATTAPULGITE,ACTIVATEDCOLLOIDAL
COLLODIALACTIVATEDATTAPULGITE,USP
Palygorskite (Mg(Al0.5-1Fe0-0.5)Si4(OH)O10.4H2O) | [EINECS(EC#)]
229-146-5 | [Molecular Formula]
2Al.3Mg.6O3Si | [MDL Number]
MFCD01774804 | [MOL File]
12174-11-7.mol | [Molecular Weight]
583.377 |
| Chemical Properties | Back Directory | [Definition]
A
hydrated aluminum-magnesium silicate, the chief
ingredient of fuller’s earth.
| [Appearance]
solid | [density ]
2.2 g/cm3 | [color ]
White or gray monoclinic or orthorhombic crystals | [Stability:]
Stable. | [Dielectric constant]
1.8（Ambient） | [Uses]
Excipient. | [IARC]
2B (Vol. 68) 1997, 3 (Vol. 68) 1997 | [EPA Substance Registry System]
Attapulgite (12174-11-7) |
| Hazard Information | Back Directory | [Chemical Properties]
solid | [Hazard]
Possible carcinogen. | [Production Methods]
Attapulgite occurs naturally as the mineral palygorskite. | [Pharmaceutical Applications]
Attapulgite is widely used as an adsorbent in solid dosage forms.
Colloidal clays (such as attapulgite) absorb considerable amounts of
water to form gels and in concentrations of 2–5% w/v usually form
oil-in-water emulsions. Activated attapulgite, which is attapulgite
that has been carefully heated to increase its absorptive capacity, is
used therapeutically as an adjunct in the management of diarrhea. | [Safety]
Attapulgite is widely used in pharmaceutical formulations and is
generally regarded as an essentially nontoxic and nonirritant
material. It is not absorbed following oral administration. In oral
preparations, activated attapulgite up to 9 g is used in daily divided
doses as an adjunct in the management of diarrhea. | [storage]
Attapulgite can adsorb water. It should be stored in an airtight
container in a cool, dry, location. | [Incompatibilities]
Attapulgite may decrease the bioavailability of some drugs such as
loperamide and riboflavin. Oxidation of hydrocortisone is
increased in the presence of attapulgite. | [Regulatory Status]
Included in nonparenteral medicines licensed in a number of
countries worldwide including the UK and USA. |
| Safety Data | Back Directory | [Safety Profile]
Suspected carcinogen with experimental neoplastigenic and tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes. | [Hazardous Substances Data]
12174-11-7(Hazardous Substances Data) | [Toxicity]
TCLo ihl-rat: 10 mg/m3/6H/13W-I:ETA BJIMAG 44,749,87 |
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