| Identification | Back Directory | [Name]
2-(6-oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidin-5-yl)acetic acid | [CAS]
1210360-87-4 | [Synonyms]
CAY10781
5-Pyrimidineacetic acid, 3,4-dihydro-4-oxo-2-(3-pyridinyl)-
2-(6-oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidin-5-yl)acetic acid | [Molecular Formula]
C11H9N3O3 | [MDL Number]
MFCD17430309 | [MOL File]
1210360-87-4.mol | [Molecular Weight]
231.21 |
| Hazard Information | Back Directory | [Biological Activity]
CAY10781 is an inhibitor of the protein-protein interaction between neuropilin-1 (NRP-1) and VEGF-A.1 It inhibits the interaction by 43% when used at a concentration of 12.5 μM. CAY10781 also inhibits VEGF-A-induced phosphorylation of VEGFR2 in catecholamine A-differentiated (CAD) cells when used at the same concentration. | [storage]
-20°C | [References]
1.Perez-Miller, S., Patek, M., Moutal, A., et al.In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike proteinbioRxiv308783(2020)
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