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ChemicalBook--->CAS DataBase List--->1202208-36-3

1202208-36-3

1202208-36-3 Structure

1202208-36-3 Structure
IdentificationBack Directory
[Name]

CAY10614
[CAS]

1202208-36-3
[Synonyms]

CAY10614
CAY10614 Exclusive
cyclopentyl-[[3,4-di(tetradecoxy)phenyl]methyl]-dimethylazanium:iodide
N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide
[Molecular Formula]

C42H78INO2
[MDL Number]

MFCD18382116
[MOL File]

1202208-36-3.mol
[Molecular Weight]

756
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 0.15 mg/ml; DMSO: 0.14 mg/ml
[form ]

A crystalline solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC50 value of 1.68 μM in a cell-based assay using modified human embryonic kidney (HEK) cells.1 It does not significantly affect HEK cell viability. In a model of sepsis, CAY10614 dramatically and significantly improves survival of mice given intraperitoneal LPS.1
[storage]

Store at -20°C
[References]

1. Piazza, M., Rossini, C., Fiorentina, S.D., et al. Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization J. Med. Chem. 52(4),1209-1213(2009).
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