| Identification | Back Directory | [Name]
GNE 900 | [CAS]
1200126-26-6 | [Synonyms]
GNE 900
GNE900; GNE 900
PPYHOOZGDDPLKM-UHFFFAOYSA-N
9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 3-[4-(1-piperidinylmethyl)phenyl]- | [Molecular Formula]
C23H21N5 | [MDL Number]
MFCD28009364 | [MOL File]
1200126-26-6.mol | [Molecular Weight]
367.45 |
| Hazard Information | Back Directory | [Description]
GNE-900 is an ATP-competitive, selective, and orally bioavailable ChK1 inhibitor. In combination with chemotherapeutic agents, GNE-900 sustains ATR/ATM signaling, enhances DNA damage, and induces apoptotic cell death. GNE-900 has little single-agent activity in the absence of chemotherapy and does not grossly potentiate the cytotoxicity of gemcitabine in normal bone marrow cells. In vivo scheduling studies show that optimal administration of the ChK1 inhibitor requires a defined lag between gemcitabine and GNE-900 administration. (Mol Cancer Ther; 12(10); 1968-80). |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
| Company Name: |
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| Tel: |
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| Website: |
www.sangon.com |
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