| Identification | Back Directory | [Name]
Niguldipine (hydrochloride) | [CAS]
119934-51-9 | [Synonyms]
Niguldipine HCl
Niguldipine Hydrochloride
DISCONTINUED PLEASE SEE N598530 | [Molecular Formula]
C36H40ClN3O6 | [MOL File]
119934-51-9.mol | [Molecular Weight]
646.18 |
| Chemical Properties | Back Directory | [storage temp. ]
RT | [solubility ]
Soluble in DMSO (up to 25 mg/ml) or in Methanol (up to 25 mg/ml). | [form ]
Yellow crystalline solid. | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
Niguldipine HCl (119934-51-9) is an L-type calcium channel blocker (IC50 = 75 nM), which can also inhibit T-type calcium channels at higher concentrations (IC50 = 244 nM). Novel inhibitor of drug transport by p-glycoprotein. | [Uses]
Niguldipine Hydrochloride is a selective α 1-adrenoceptor antagonist. Also, it is a new calcium antagonist. | [in vitro]
niguldipine significantly increased the rate of long-lived protein degradation in human glioblastoma h4 cell, which indicated that niguldipine triggered autophagic degradation without inducing obvious cellular damage. also, niguldipine blocked intracellular ca2+ currents [1]. | [in vivo]
female albino swiss mice were administered intraperitoneally in a volume of 10 ml/kg niguldipine for 30 min. niguldipine did not affect the electroconvulsive threshold in mice. compared to the anticonvulsive activity of niguldipine against electroconvulsions, niguldipine remarkably impaired the protective action of both phenobarbital and carbamazepine [2]. | [IC 50]
s = 0.4 μm: inhibits l-type ca2+ channels | [storage]
Store at -20°C | [References]
1) Stengel et al. (1998), Different potencies of dihydropyridine derivatives in blocking T-type but not L-type Ca2+ channels in neuroblastoma-glioma hybrid cells; Eur. J. Pharmacol., 342 339
2) Hollt et al. (1992), Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein; Biochem. Pharmacol., 43 2601 |
|
|