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ChemicalBook--->CAS DataBase List--->1198080-03-3

1198080-03-3

1198080-03-3 Structure

1198080-03-3 Structure
IdentificationBack Directory
[Name]

Propargyl-PEG6-azide
[CAS]

1198080-03-3
[Synonyms]

Propargyl-PEG6-N3
Propargyl-PEG6-azide
Azido-PEG6-propargyl
[Molecular Formula]

C15H27N3O6
[MDL Number]

MFCD31561110
[MOL File]

1198080-03-3.mol
[Molecular Weight]

345.4
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Biological Activity]

Propargyl-PEG6-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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