| Identification | Back Directory | [Name]
2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride | [CAS]
1197376-85-4 | [Synonyms]
INC-280 2HCl
INCB28060 2HCl
Capmatinib 2HCl
INCB28060 Dihydrochloride
Capmatinib Dihydrochloride
2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride | [EINECS(EC#)]
695-736-8 | [Molecular Formula]
C23H19Cl2FN6O | [MDL Number]
MFCD30502991 | [MOL File]
1197376-85-4.mol | [Molecular Weight]
485.341 |
| Hazard Information | Back Directory | [Description]
INCB28060 Dihydrochloride is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM. | [Uses]
INCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro. |
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