| Identification | Back Directory | [Name]
5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide | [CAS]
1189987-23-2 | [Synonyms]
5-methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
Leflunomide-d4Q: What is
Leflunomide-d4 Q: What is the CAS Number of
Leflunomide-d4 Q: What is the storage condition of
Leflunomide-d4 Q: What are the applications of
Leflunomide-d4 | [Molecular Formula]
C12H9F3N2O2 | [MDL Number]
MFCD06658907 | [MOL File]
1189987-23-2.mol | [Molecular Weight]
270.21 |
| Hazard Information | Back Directory | [Uses]
An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases.This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research. | [Biological Activity]
Leflunomide-d4 is intended for use as an internal standard for the quantification of leflunomide by GC- or LC-MS. Leflunomide is a synthetic isoxazol and a prodrug form of A-771726 , a dihydroorotate dehydrogenase inhibitor.1 Leflunomide inhibits de novo pyrimidine synthesis to regulate T lymphocyte progression through the cell cycle. It inhibits proliferation and activation of T cells when used at concentrations of 25 and 100 μM, respectively, for na?ve and memory CD4+ T cells.2 It also reduces the production of Th1 effector cells and increases differentiation of Th2 cells in vitro and in splenocytes isolated from KLH-immunized mice. Leflunomide (35 mg/kg per day) reduces and prevents inflammation in a proteoglycan-induced mouse model of rheumatoid arthritis.3 Formulations containing leflunomide have been used in the treatment of active rheumatoid arthritis. | [References]
1.Breedveld, F.C., and Dayer, J.-M.Leflunomide: Mode of action in the treatment of rheumatoid arthritisAnn. Rheum. Dis.59(11)841-849(2000)
2.Dimitrova, P., Skapenko, A., Herrmann, M.L., et al.Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiationJ. Immunol.169(6)3392-3399(2002)
3.Glant, T.T., Mikecz, K., Bartlett, R.R., et al.Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomideImmunopharmacology23(2)105-116(1992)
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