| Identification | Back Directory | [Name]
5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID | [CAS]
118414-59-8 | [Synonyms]
NTZDPA
5-Chloro-1-(4-chlorobenzyl)-3-(phenylthio)-1H-indole-2-carboxylic acid
5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID
1H-Indole-2-carboxylic acid, 5-chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)- | [Molecular Formula]
C22H15Cl2NO2S | [MDL Number]
MFCD06798322 | [MOL File]
118414-59-8.mol | [Molecular Weight]
428.33 |
| Hazard Information | Back Directory | [Uses]
nTZDpa is a PPARγ agonist, with pharmaceutical applications such as anti-diabetic drugs. | [Biological Activity]
Potent, selective non-thiazolidinedione PPAR γ partial agonist (EC 50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC 50 ~ 285 nM). Displays no activity at PPAR α or PPAR δ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR γ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo . | [storage]
Store at -20°C |
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