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ChemicalBook--->CAS DataBase List--->117997-17-8

117997-17-8

117997-17-8 Structure

117997-17-8 Structure
IdentificationBack Directory
[Name]

TAUROHYOCHOLATE
[CAS]

117997-17-8
[Synonyms]

TAUROHYOCHOLATE
[Molecular Formula]

C26H45NO7S
[MOL File]

117997-17-8.mol
[Molecular Weight]

515.703
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
[form ]

A lyophilized powder
Hazard InformationBack Directory
[Biological Activity]

Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .1 THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline phase.2 It prevents cholestasis and cellular necrosis induced by taurolithocholic acid in isolated rat livers.3 THCA levels are increased in the urine of patients with hepatitis B-induced cirrhosis.4
[storage]

Store at -20°C
[References]

1.Wahlstr?m, A., Sayin, S.I., Marschall, H.-I., et al.Intestinal crosstalk between bile acids and microbiota and its impact on host metabolismCell Metab.24(1)41-50(2016) 2.Juste, C., Catala, I., Henry, R., et al.Influence of bile salt molecular species on cholesterol crystallization from supersaturated model bilesBiochim. Biophys. Acta.1254(1)89-97(1995) 3.Scholmerich, J., Kitamura, S., Baumgartner, U., et al.Taurohyocholate, taurocholate, and tauroursodeoxycholate but not tauroursocholate and taurodehydrocholate counteract effects of taurolithocholate in rat liverRes. Exp. Med. (Berl.)190(2)121-129(1990) 4.Wang, X., Xie, G., Zhao, A., et al.Serum bile acids are associated with pathological progression of hepatitis B-induced cirrhosisJ. Proteome Res.15(4)1126-1134(2016)
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