| Identification | Back Directory | [Name]
N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]-8-methylnonanamide | [CAS]
1177195-52-6 | [Synonyms]
N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]-8-methylnonanamide
Nonanamide, N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]-8-methyl- | [Molecular Formula]
C18H28INO3 | [MDL Number]
MFCD08062158 | [MOL File]
1177195-52-6.mol | [Molecular Weight]
433.324 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2)(1:2): .25 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper.1 Capsaicin signals are transduced by a heat-activated ion channel, the vanilloid receptor 1 (VR1), or transient receptor potential vanilloid 1 (TRPV1).2 CAY10448 is an iodinated nonivamide, a potent capsaicin receptor antagonist with an IC50 value of approximately 10 nM.3 | [storage]
Store at -20°C | [References]
1. Gannett, P.M., Nagel, D.L., Reilly, P.J., et al. The capsaicinoids: Their separation, synthesis, and mutagenicity J. Org. Chem. 53(5),1064-1071(1988).
2. Caterina, M.J., Schumacher, M.A., Tominaga, M., et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway Nature 389,816-824(1997).
3. Daddario, N., Minassi, A., Appendino, G., et al. The taming of capsaicin. Synthesis and vanilloid antagonistic activity of isosteric and regioisomeric halononiv amides and their products of halogen-carbon exchange 14th Annual Symposium on the Cannabinoids ,137-137(2004). |
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