| Identification | Back Directory | [Name]
D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID | [CAS]
117414-74-1 | [Synonyms]
D-CPP-ENE
Midafotel
DCPPene,D CPP ene
(R,E)-4-(3-PHOSPHONOPROP-2-ENYL)PIPERAZINE-2-CARBOXYLIC ACID
D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID
(2R)-4-[(E)-3-Phosphono-2-propenyl]piperazine-2β-carboxylic acid
2-Piperazinecarboxylic acid, 4-[(2E)-3-phosphono-2-propenyl]-, (2R)- | [Molecular Formula]
C8H15N2O5P | [MDL Number]
MFCD00878116 | [MOL File]
117414-74-1.mol | [Molecular Weight]
250.19 |
| Hazard Information | Back Directory | [Uses]
D-CPP-ene is a potent, competitive NMDA antagonist (1). NMDA antagonists such as this may increase sucrose intake through hunger satiation delay (2). | [Definition]
ChEBI: Midafotel is a member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and was in clinical development by Novartis for the treatment of cognition disorders and brain injuries (now discontinued). It has a role as a NMDA receptor antagonist, a neuroprotective agent and an anticonvulsant. It is a piperazinecarboxylic acid, a monocarboxylic acid, a member of phosphonic acids, an olefinic compound and a tertiary amino compound. | [Biological Activity]
Potent and competitive NMDA antagonist (K i = 40 nM). Centrally active following systemic administration. | [storage]
Desiccate at RT |
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