| Identification | Back Directory | [Name]
BMS 665053 | [CAS]
1173435-64-7 | [Synonyms]
BMS 665053
BMS-665053 >=98% (HPLC)
5-chloro-1-[(1S)-1-cyclopropylethyl]-3-[2,6-dichloro-4-(difluoromethoxy)anilino]pyrazin-2-one
2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropylethyl]-3-[[2,6-dichloro-4-(difluoromethoxy)phenyl]amino]- | [Molecular Formula]
C16H14Cl3F2N3O2 | [MDL Number]
MFCD28977961 | [MOL File]
1173435-64-7.mol | [Molecular Weight]
424.66 |
| Chemical Properties | Back Directory | [storage temp. ]
room temp | [solubility ]
DMSO: 20mg/mL, clear | [form ]
powder | [color ]
white to light brown | [optical activity]
[α]/D +16 to +21°, c = 0.4 in chloroform-d |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
BMS-665053 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 10 μM against 150 pM ovine CRF in binding assay). BMS-665053 exhibits anxiolytic efficacy in a defensive withdrawal anxiety test in rats in vivo (10 mg/kg p.o.) with good oral bioavailability (F = 52%). |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|