| Identification | Back Directory | [Name]
Nitecapone | [CAS]
116313-94-1 | [Synonyms]
OR 462
Nitecapone
3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione
3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione | [Molecular Formula]
C12H11NO6 | [MDL Number]
MFCD00866318 | [MOL File]
116313-94-1.mol | [Molecular Weight]
265.22 |
| Questions And Answer | Back Directory | [Description]
Nitecapone (OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).It was patented as an antiparkinson medication. | [In vitro]
Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.MCE has not independently confirmed the accuracy of these methods. They are for reference only. | [Biological activity]
Nitecapone (OR-462) is a short-acting, orally active, catechol-O-methyltransferase (COMT) inhibitor with gastrointestinal protective and antioxidant activity. Nitecapone (OR-462) scavenges reactive oxygen species and nitric oxide and prevents lipid peroxidation. |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Toxicity]
mouse,LD50,intraperitoneal,507mg/kg (507mg/kg),Pharmacology and Toxicology Vol. 69, Pg. 64, 1991. |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
Inhibitor for the treatment of Parkinson disease | [Uses]
Inhibitor for the treatment of Parkinson's disease. | [Definition]
ChEBI: Nitecapone is a hydroxycinnamic acid. |
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