| Identification | Back Directory | [Name]
2,6-DICHLORO-5-FLUORONICOTINAMIDE | [CAS]
113237-20-0 | [Synonyms]
CPD2809-A1
2,6-DICHLORO-5-FLUORONICOTIMIDE
2,6-DICHLORO-5-FLUORONICOTINAMIDE
2,6-Dichloro-5-fluoronicotinamide97%
2,6-Dichloro-5-fluoronicotinamide 97%
2,6-dichloro-3-carboxamide-5-fluoropyridine
2,6-DICHLORO-5-FLUOROPYRIDINE-3-CARBOXAMIDE
3-PyridinecarboxaMide, 2,6-dichloro-5-fluoro-
2,6-DICHLORO-5-FLUORONICOTINAMIDE ISO 9001：2015 REACH
2,6-Dichloro-5-fluoropyridine-3-carboxamide, 3-Carbamoyl-2,6-dichloro-5-fluoropyridine | [Molecular Formula]
C6H3Cl2FN2O | [MDL Number]
MFCD01571365 | [MOL File]
113237-20-0.mol | [Molecular Weight]
209.01 |
| Chemical Properties | Back Directory | [Melting point ]
160-162 | [Boiling point ]
259.0±40.0 °C(Predicted) | [density ]
1.614±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
crystalline solid | [pka]
13.36±0.50(Predicted) | [color ]
White | [InChI]
InChI=1S/C6H3Cl2FN2O/c7-4-2(6(10)12)1-3(9)5(8)11-4/h1H,(H2,10,12) | [InChIKey]
ZVYNUGSPFZCYEV-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC(Cl)=C(F)C=C1C(N)=O |
| Hazard Information | Back Directory | [Uses]
2,6-Dichloro-5-fluoronicotinamide is a fluorinated pharmaceutical intermediate compound used in the synthesis of Sotorasib and AMG 510. Sotorasib is a RAS GTPase family inhibitor used for the treatment of KRAS-mutated solid tumours including non-small cell lung cancer (NSCLC) and colorectal cancer. |
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