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ChemicalBook--->CAS DataBase List--->110880-55-2

110880-55-2

110880-55-2 Structure

110880-55-2 Structure
IdentificationBack Directory
[Name]

(SAR9,MET(O2)11)-SUBSTANCE P
[CAS]

110880-55-2
[Synonyms]

Bhsar-sp
[Sar9, Met(O2)11
[Sar9]SP sulfone
[Sar9]SP sulphone
RPKPQQFFSARLM(O2)
[Sar9,Met(O2)11]SP
9-Sar-substance p sulfone
[Sar9]substance P sulphone
9-Sar-11-Met(o2)-substance p
(SAR9,MET(O2)11)-SUBSTANCE P
Sarcosyl(9)-substance p sulfone
substance P, Sar(9)-Met(O2)(11)-
[SAR9,MET(O2)11]-SUBSTANCE P?, >98%
(SAR9,MET(O2)11)-SUBSTANCE P USP/EP/BP
9-Sarcosyl-11-methionine(o2)-substance p
Bolton hunter-9-sar-11-Met(02)-substance p
Substance P, 9-(N-methylglycine)-, S,S-dioxide
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-SAR-LEU-MET(O2)-NH2
H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-SAR-LEU-MET(O2)-NH2
Bolton-hunter reagent-substance p. sar(9)-Met(02)(11)
[Sar9,met(o2)11]-substancephighlyspecificneurokininnk1receptor
[SAR9 ,MET(O2 )11 ]-SUBSTANCE P HIGHLY SPECIFIC NEUROKININ NK1 RECEPTOR 97+%
L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Sar-L-Leu-4-(Methylsulfonyl)-L-Abu-NH2
[Sar9,Met(O2)11]-Substance P,Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O2]-NH2?, >98%
(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfonyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide
[Molecular Formula]

C64H100N18O15S
[MDL Number]

MFCD00076787
[MOL File]

110880-55-2.mol
[Molecular Weight]

1393.66
Chemical PropertiesBack Directory
[density ]

1.43±0.1 g/cm3(Predicted)
[storage temp. ]

−20°C
[solubility ]

H2O : 50 mg/mL (35.88 mM; Need ultrasonic)
[form ]

Lyophilized solid.
[pka]

13.31±0.20(Predicted)
[color ]

White to off-white
[Water Solubility ]

Soluble to 1 mg/ml in water
[Sequence]

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-NH2
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

[Sar9,Met(O2)11]-Substance P is a potent and selective NK1 tachykinin receptor agonist (1). The NK1 tachykinin receptor is a member of the G-protein coupled receptor family and can be found in neurons, brainstem, and vascular endothelial cells (2,3). NK1 tachykinin receptor is a therapeutic target for pancreatic cancer (4).
[Biochem/physiol Actions]

Highly selective NK-1 receptor agonist.
[storage]

Desiccate at -20°C
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