| Identification | Back Directory | [Name]
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN | [CAS]
11002-13-4 | [Synonyms]
DRVYIHPFHLVIHN
ANGIOTENSINOGEN
RENIN SUBSTRATE
hypertensinogen
ANGIOTENSINOGEN 1-14
RENIN SUBSTRATE, HUMAN
PREANGIOTENSINOGEN 1-14
HUMAN PREANGIOTENSINOGEN 1-14
ANGIOTENSINOGEN FRAGMENT 1-14
ANGIOTENSINOGEN (1-14) (HUMAN)
RENIN SUBSTRATE TETRADECAPEPTIDE
PREANGIOTENSINOGEN (1-14) (HUMAN)
angiotensinogen from human plasma
Hypertensinogen, Renin substrate
RENIN SUBSTRATE TETRADECAPEPTIDE HUMAN
TETRADECAPEPTIDE RENIN SUBSTRATE (HUMAN)
ANGIOTENSINOGEN FROM HUMAN PLASMALYOPHIL IZED
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN-OH
H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN-OH | [Molecular Formula]
C83H122N24O19 | [MDL Number]
MFCD00133096 | [MOL File]
11002-13-4.mol | [Molecular Weight]
1760.01 |
| Hazard Information | Back Directory | [Biological Functions]
Human plasma contains a glycoprotein called angiotensinogen,
which serves as the only known substrate
for renin. Angiotensinogen must undergo proteolysis
before active portions of the protein are sufficiently unmasked
to exert biological effects. Angiotensinogen is
synthesized in many organs, including the liver, brain,
kidney, and fat. Its gene transcription and plasma concentrations
increase following treatment with adrenocorticotropic
hormone (ACTH), glucocorticoids, thyroid
hormone, and estrogens, as well as during
pregnancy and inflammation and after nephrectomy.
Angiotensinogen also has been found in large quantities
in cerebrospinal and amniotic fluid. Mutations in
the angiotensinogen gene have been reported to be
linked to human hypertension. |
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SIGMA-RBI
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