| Identification | Back Directory | [Name]
dendrophenol | [CAS]
108853-14-1 | [Synonyms]
Aloifol II
Moscatilin
dendrophenol
Gigantol(Dendrophenol)
4，4'-Dihydroxy-3，3'，5-trimethoxybibenzyl
4-(4-hydroxy-3-methoxyphenethyl)-2,6-dimethoxyphenol
4-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-2,6-dimethoxy-phenol
Phenol,4-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2,6-dimethoxy- | [EINECS(EC#)]
300-009-3 | [Molecular Formula]
C17H20O5 | [MOL File]
108853-14-1.mol | [Molecular Weight]
304.338 |
| Chemical Properties | Back Directory | [Melting point ]
87-89℃ (ethyl ether ) | [Boiling point ]
454.1±40.0 °C | [density ]
1.208±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
10.09±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Dendrophenol can be used to protect against high glucose-evoked nephrotoxicity in vivo. It can be used with HPLC-PDA-HRMS-SPE-NMR for determination of its inhibitive activities. | [in vivo]
Dendrophenol (10 mg/kg; intraperitoneal injection; 3 weeks) has a beneficial effect in the mouse model of vascular calcification[3].
Dendrophenol (50-100 mg/kg; intraperitoneal injection; 5 times a week for 2 weeks) has antitumor effect in mouse tumor model[4]. | Animal Model: | Nicotine and Vitamin D3 (HY-15398) treated male C57BL/6J mice aged 25 weeks old[3] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection (i.p.); 3 weeks | | Result: | Reduced calcium accumulation in the thoracic aorta and aortic valves of the mice.
Reduced the expression of calcification-related genes, such as ALPL, BMP2 and RUNX2.
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| Animal Model: | HCT-116 cells treated male severe combined immunodeficient mice[4] | | Dosage: | 50 and 100 mg/kg | | Administration: | Intraperitoneal injection (i.p.); five times a week for two weeks | | Result: | Significantly inhibited tumor growth and did not result in weight loss.
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| [IC 50]
NF-κB; COX-2; HIF-1α |
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