| Identification | Back Directory | [Name]
FH 535 | [CAS]
108409-83-2 | [Synonyms]
FH 535
CS-1433
FH 535(FH-535)
FH 535 USP/EP/BP
FH535;FH 535;FH-535
β-Catenin/Tcf Inhibitor, FH535
N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonaMide
2,5-Dichloro-N-(2-Methyl-4-nitrophenyl)benzenesulfonaMide
Benzenesulfonamide, 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-
β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem
FH535, 98%, a cell-permeable compound that inhibits Wnt/β-catenin and PPAR
2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide FH535 | [Molecular Formula]
C13H10Cl2N2O4S | [MDL Number]
MFCD01212888 | [MOL File]
108409-83-2.mol | [Molecular Weight]
361.2 |
| Chemical Properties | Back Directory | [Melting point ]
141-142℃ | [Boiling point ]
526.3±60.0 °C(Predicted) | [density ]
1.566±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL | [form ]
Yellow solid | [pka]
5.83±0.10(Predicted) | [color ]
Tan | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. | [InChIKey]
AXNUEXXEQGQWPA-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Description]
FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1 but not the corepressors NCoR and SMRT.1?Inhibits the migration and growth of breast cancer cell lines2 as well as colon, lung and liver cell lines1. FH-535 is a useful tool for probing the involvement of Wnt signaling pathway.3,4 | [Chemical Properties]
Dark Yellow Solid | [Uses]
A cell-permeable compound that inhibits Wnt/β-catenin and PPAR | [Uses]
Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways. | [Definition]
ChEBI: 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is a sulfonamide. | [Biochem/physiol Actions]
FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells. | [storage]
+4°C | [References]
1) Handeli et al. (2008), A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities; Mol. Cancer Ther., 7 521
2) Iida et al. (2012), FH535 inhibited migration and growth of breast cancer cells; PLoS One, 7 e44418
3) Frewer et al. (2013), A role for WISP2 in colorectal cancer cell invasion and motility; Cancer Genomics Proteomics, 10 187
4) Polk et al. (2012), FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling; Int. J. Toxicol., 31 380
5) Morita and Hayashi (2018), Tumor Progression is Mediated by Thymosin-β4 through a TGFβ/MRTF Signaling Axis; Mol. Cancer Res. 16(5) 880 |
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