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ChemicalBook--->CAS DataBase List--->107615-77-0

107615-77-0

107615-77-0 Structure

107615-77-0 Structure
IdentificationBack Directory
[Name]

11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
[CAS]

107615-77-0
[Synonyms]

VKTIONYPMSCHQI-KGILNJEGSA-N
11β-13,14-dihydro-15-keto Prostaglandin F2α
11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
9ALPHA, 11BETA-DIHYDROXY-15-OXO-PROST-5Z-EN-1-OIC ACID
[Molecular Formula]

C20H34O5
[MDL Number]

MFCD00216071
[MOL File]

107615-77-0.mol
[Molecular Weight]

354.48
Chemical PropertiesBack Directory
[solubility ]

10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a)
Safety DataBack Directory
[Symbol(GHS) ]


GHS02,GHS07
[Signal word ]

Danger
[Hazard statements ]

H225-H319-H336
[Precautionary statements ]

P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
Hazard InformationBack Directory
[Description]

11β-13,14-dihydro-15-keto PGF is a metabolite of PGD2 in the 15-hydroxy PGDH pathway.1,2 Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF, as the immediate product, and 11β-13,14-dihydro-15-keto PGF in the plasma within 10 minutes.1 Homogenates of human lung metabolize PGD2 first to 11β-PGF and then to 11β-15-keto-PGF in the presence of NAD+, but not 11β-13,14-dihydro-15-keto PGF.2 Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF, via 11β-PGF, in the presence of NAD+ and NADP+.2
[Definition]

ChEBI: 11beta-13,14-dihydro-15-keto-PGF2alpha is a prostanoid.
[References]

1. Robinson, C., Hardy, C.C., and Holgate, S.T. The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men Biochim. Biophys. Acta 963(2),151-161(1988).
2. Robinson, C., Herbert, C.A., Bedwell, S., et al. The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways Biochem. Pharmacol. 38(19),3267-3271(1989).
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