| Identification | Back Directory | [Name]
GYY 4137 Morpholine salt | [CAS]
106740-09-4 | [Synonyms]
GYY 4137
GYY 4137 MORPHOLINE SALT
GYY4137;GYY-4137;GYY 4137
morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate
4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt
P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt
(4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine
(4-methoxyphenyl)-morpholin-4-yl-sulfanylidene-sulfido-λ5-phosphane,morpholin-4-ium | [Molecular Formula]
C15H25N2O3PS2 | [MDL Number]
MFCD18428020 | [MOL File]
106740-09-4.mol | [Molecular Weight]
376.474 |
| Hazard Information | Back Directory | [Description]
Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor. When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation. | [Uses]
Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor. When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation.[Cayman Chemical] | [storage]
+4°C |
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