| Identification | Back Directory | [Name]
MK6-83 | [CAS]
1062271-24-2 | [Synonyms]
MK6-83
spudl 05344
5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
2-Thiophenesulfonamide, 5-methyl-N-[2-(1-piperidinyl)phenyl]-
MK6-83,fibroblast,lysosome,Mucolipidosis,Transient receptor potential channels,cell,inhibit,MK6 83,TRP Channel,MK-6-83,Inhibitor | [Molecular Formula]
C16H20N2O2S2 | [MDL Number]
MFCD10736412 | [MOL File]
1062271-24-2.mol | [Molecular Weight]
336.47 |
| Chemical Properties | Back Directory | [Melting point ]
115 - 116°C | [Boiling point ]
502.6±60.0 °C(Predicted) | [density ]
1.311±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), DMSO (Slightly) | [form ]
Solid | [pka]
8.56±0.50(Predicted) | [color ]
Pale Brown |
| Hazard Information | Back Directory | [Uses]
MK6-83 is a TRPML channel activator, restoring endolysosomal trafficking and zinc homeostasis lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts. | [Biological Activity]
MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.''MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells. | [storage]
Store at +4°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|