| Identification | Back Directory | [Name]
m-PEG7-aldehyde | [CAS]
1058691-77-2 | [Synonyms]
MPEG7-ALD
mPEG7-CHO
mPEG7-pAld
m-PEG7-aldehyde
m-PEG9-aldehyde
MPEG7-CH2CH2CHO
m-PEG6-CH2CH2CHO
4,7,10,13,16,19,22-Heptaoxatricosanal | [Molecular Formula]
C16H32O8 | [MDL Number]
MFCD28976707 | [MOL File]
1058691-77-2.mol | [Molecular Weight]
352.42 |
| Hazard Information | Back Directory | [Description]
m-PEG7-aldehyde is a PEG reagent containing an aldehyde group. Aldehyde can react with hydrazide and aminooxy groups for labeling and crosslinking carbonyls. | [Biological Activity]
M-PEG7-aldehyde is a non-cleavable ADC linker for antibody drug conjugate (ADC) synthesis,it is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | [target]
| Non-cleavable < span> | PEGs | |
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