| Identification | Back Directory | [Name]
Azido-dPEG4-acid | [CAS]
1056024-94-2 | [Synonyms]
N3-PEG3-COOH
Azido-dPEG4-acid
N3-PEG3-CH2CH2COOH
N3-PEG3-COOH,Azido-PEG3-acid
N3-(CH2)2-O-(CH2-CH2-O)2-(CH2)2-COOH | [Molecular Formula]
C9H17N3O5 | [MDL Number]
MFCD23726617 | [MOL File]
1056024-94-2.mol | [Molecular Weight]
247.25 |
| Hazard Information | Back Directory | [Description]
Azido-PEG3-acid is a crosslinker containing an azide(N3) group with a carboxylic acid (CO2H). The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. | [Definition]
ChEBI: 3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid is an organonitrogen compound. | [Biological Activity]
Azido-dPEG4-acid is a PEG-based PROTAC linker for the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. It is also a non-cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
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