| Identification | Back Directory | [Name]
ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINEBUTANOL HYDROCHLORIDE | [CAS]
105565-55-7 | [Synonyms]
BMS-181100
BMY-14802-1
BMY14802HyClHCl
BMY 14802 HYDROCHLORIDE
α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanolhydrochloride
ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINEBUTANOL HYDROCHLORIDE | [Molecular Formula]
C18H23ClF2N4O | [MDL Number]
MFCD04039786 | [MOL File]
105565-55-7.mol | [Molecular Weight]
384.85 |
| Hazard Information | Back Directory | [Uses]
BMY 14802 Hydrochloride was studied to be a potential atypical antipsychotic agent. | [Biological Activity]
Potent sigma receptor antagonist (IC 50 = 112 nM) with modest to weak affinity for 5-HT 1A and α 1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems. | [in vitro]
bmy 14802 has its most potent binding at the sigma binding site, with some degree of serotonin subtype 1a and negligible dopamine receptor binding [1]. | [in vivo]
bmy 14802 is atypical of standard neuroleptics in that it does not induce catalepsy in rats. in addition, it has been shown to have efficacy in animal models of psychosis [1]. | [IC 50]
112 nm for (+)-[3h]-3-ppp | [References]
[1] gewirtz gr, gorman jm, volavka j, macaluso j, gribkoff g, taylor dp, borison r. bmy 14802, a sigma receptor ligand for the treatment of schizophrenia. neuropsychopharmacology. 1994 feb;10(1):37-40. |
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