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ChemicalBook--->CAS DataBase List--->1050480-30-2

1050480-30-2

1050480-30-2 Structure

1050480-30-2 Structure
IdentificationBack Directory
[Name]

PhiKan 083 hydrochloride
[CAS]

1050480-30-2
[Synonyms]

PhiKan083 hydrochloride >=98% (HPLC)
[Molecular Formula]

C16H19ClN2
[MOL File]

1050480-30-2.mol
[Molecular Weight]

274.79
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble to 50 mM in water and to 100 mM in DMSO
[form ]

Solid
[color ]

White to off-white
[Water Solubility ]

Water: 2 mg/mL (7.28 mM and warming)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319
[Precautionary statements ]

P305+P351+P338
Hazard InformationBack Directory
[Uses]

PhiKan-083 is a p53 stabilizing agent. PhiKan-083 preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. PhiKan-083 slows rate of thermal denaturation of p53-Y220C.
[Biological Activity]

PhiKan083 is a small molecule th at binds within a cavity on the surface of Y220C-mutated p53. This mutationwhich is not involved in DNA interactioncauses a destabilization of the protein. PhiKan083 binding acts to stabilize the mutant p53 and slow the rate of denaturation.
[storage]

Store at +4°C
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