| Identification | Back Directory | [Name]
Cyclohexanecarboxamide, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]- | [CAS]
104676-09-7 | [Synonyms]
Cyclohexanecarboxamide, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]- | [Molecular Formula]
C12H16N2O3 | [MDL Number]
MFCD33023408 | [MOL File]
104676-09-7.mol | [Molecular Weight]
236.27 |
| Chemical Properties | Back Directory | [Boiling point ]
468.5±14.0 °C(Predicted) | [density ]
1.280±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
16.71±0.40(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Biological Activity]
MCC is non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as MCC-DM1[1].
Antibody-drug conjugates (ADCs) are potent cytotoxic drugs linked to antibodies through chemical linkers, and allow specific targeting of drugs to neoplastic cells. Anti-CD22-MCC-DM1 is broadly effective in vitro against multiple NHL cell lines[1]. | [References]
[1]. Polson AG, et al. Anti-CD22-MCC-DM1: an antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma. Leukemia. 2010;24(9):1566-1573. |
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