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ChemicalBook--->CAS DataBase List--->103878-83-7

103878-83-7

103878-83-7 Structure

103878-83-7 Structure
IdentificationBack Directory
[Name]

N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
[CAS]

103878-83-7
[Synonyms]

TeMpiuM
Ro 19-6327/001
JMFKTFLARGGXCC-UHFFFAOYSA-N
N-(2-Aminoethyl)-5-chlor-2-pyridincarbox
N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride
2-PyridinecarboxaMide, N-(2-aMinoethyl)-5-chloro-, Monohydrochloride
[Molecular Formula]

C8H10ClN3O.HCl
[MOL File]

103878-83-7.mol
Chemical PropertiesBack Directory
[Melting point ]

193-195°
[storage temp. ]

Desiccate at RT
[solubility ]

Soluble to 100 mM in water and to 100 mM in DMSO
[form ]

Powder
[pka]

8.9(at 25℃)
Hazard InformationBack Directory
[Uses]

Treatment of Alzheimer’s disease.
[Definition]

ChEBI: Lazabemide hydrochloride is a pyridinecarboxamide.
[Brand name]

Tempium (Hoffmann-LaRoche).
[Biological Activity]

Selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC 50 values are 0.03 and > 100 μ M for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC 50 values are 86, 123 and > 500 μ M for noradrenalin, serotonin and dopamine uptake respectively).
[storage]

Desiccate at RT
Safety DataBack Directory
[Toxicity]

LD50 orally in mice: 1000-2000 mg/kg (Imhof, Kyburz, 1986)
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