| Identification | Back Directory | [Name]
8-BROMOTHEOPHYLLINE | [CAS]
10381-75-6 | [Synonyms]
Nsc164940
AKOS NCG-0005
bromotheophylline
8-Bromotheophyline
8-BROMOTHEOPHYLLINE
LABOTEST-BB LT00134545
Theophylline, 8-bromo-
8-BROMOTHEOPHYLLINE 97%
8-Bromotheophylline ,97%
1,3-Dimethyl-8-bromoxanthine
8-Bromotheophylline (400 mg)
8-BroMo-1,3-diMethyl-1H-purine-2,6(3H,9H)-dione
8-broMo-1,3-diMethyl-1H-purine-2,6(3H,7H)-dione
8-BROMO-1,3-DIMETHYL-3,7-DIHYDRO-PURINE-2,6-DIONE
8-bromo-3,7-dihydro-1,3-dimethyl-1h-purine-6-dione
8-BROMO-3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE
8-Bromo-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
1H-Purine-2,6-dione, 8-bromo-3,7-dihydro-1,3-dimethyl-
8-bromo-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione(SALTDATA: FREE) | [EINECS(EC#)]
233-846-6 | [Molecular Formula]
C7H7BrN4O2 | [MDL Number]
MFCD00022664 | [MOL File]
10381-75-6.mol | [Molecular Weight]
259.06 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Powder | [Uses]
The active component in the diuretic Diurex. | [Description]
Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome. Bromotheophylline is categorized on the FDA as a drug substance with an inactive state since March, 1980. It is also approved by Health Canada to be used alone or in combination with [DB00316] in OTC products. | [Purification Methods]
It is purified by dissolving in the minimum volume of dilute NaOH (charcoal), filtering and acidifying to pH ca 3.5-4. The solid that separates is collected, dried in vacuo at 100o and stored in a dark container. It has also been recrystallised from EtOH or AcOH. [Blitz & Beck J Prakt Chem [2] 118 158 1928, Fischer & Ach Chem Ber 28 3142 1895, Beilstein 26 H 476, 26 II 227, 26 III/IV 2447.] |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Nitric acid-->Acetic anhydride-->Hydrogen bromide-->Theophylline | [Preparation Products]
8-BROMO-7-(2,3-DIHYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-2,6-PURINEDIONE-->Purino[8,7-b]quinazoline-2,4,6(1H,3H,11H)-trione, 1,3-dimethyl- (9CI)-->8-anilino-1,3-dimethyl-7H-purine-2,6-dione-->8-BROMO-7-(3-CHLOROPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE |
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