| Identification | Back Directory | [Name]
CTAP | [CAS]
103429-32-9 | [Synonyms]
CTAP
CTAP-NH2
CTAP,CTA
CTAP, ≥95%
7)-disulfide
CYS2, TYR3, ARG5, PEN7-AMIDE
M.W. 1104.30 C51H69N13O11S2
D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2
H-D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2
D-Phe-L-Cys-L-Tyr-D-Trp-L-Arg-L-Thr-L-Pen-L-Thr-NH2
H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2(Cys2-Pen7)
D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2(DISULFIDE BRIDGE:CYS2-PEN7)
H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (Disulfide bond between Cys2 and Pen7)
L-Threoninamide,D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-arginyl-L-threonyl-3-mercapto-L-valyl-,cyclic (2®
D-Phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-arginyl-L-threonyl-3-mercapto-L-valyl-L-threoninamide cyclic (2→
D-Phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-arginyl-L-threonyl-3-mercapto-L-valyl-L-threoninamide cyclic (2-7)-disulfide
L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-arginyl-L-threonyl-3-mercapto-L-valyl-, cyclic (2→7)-disulfide | [Molecular Formula]
C51H69N13O11S2 | [MDL Number]
MFCD00671434 | [MOL File]
103429-32-9.mol | [Molecular Weight]
1104.3 |
| Hazard Information | Back Directory | [Uses]
CTAP acts as a selective μ-opioid receptor antagonist with a multitude of applications including the regulation of aggressive behavior in mammals. Activation of μ-opioid receptors in the central nucleus of the amygdala, is responsible for mechanisms related to the control of sodium appetite and regulation of sodium intake. | [Uses]
CTAP has been used as a μ-opioid receptor (MOR) antagonist:
- to study the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitor isoleucine-proline-isoleucine (IPI) and vildagliptin in carrageenan-induced inflammation
- to study the role of MOR in glutamate and gamma-aminobutyric acid (GABA) efflux during predator stress in rats
- to determine the endogenous opioid peptide involved in blocking pain induced by activated gastrin-releasing peptide (Grp+) neurons
| [Biochem/physiol Actions]
CTAP is a peptide antagonist produced from somatostatin analogs. | [storage]
Desiccate at -20°C |
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