| Identification | Back Directory | [Name]
DHP 218 | [CAS]
102097-78-9 | [Synonyms]
PAK9
PAK-9
PAK 9
DHP 218
2-[1,4-Dihydro-2,6-dimethyl-3-(methoxycarbonyl)-4-(2-nitrophenyl)pyridin-5-yl]-1,3,2-dioxaphosphorinane 2-oxide | [MDL Number]
MFCD30564998 | [MOL File]
102097-78-9.mol |
| Hazard Information | Back Directory | [Description]
DHP-218, also known as PAK-9, is a calcium channel antagonist potentially for the treatment of hypertension and myocardia ischemia. Calcium-induced contraction of the rat aorta in high K+ solution was inhibited by DHP-218 with the pA2 value of 9.11. The IC50 value for the inhibitory effects of this compound in high K+-induced and phenylephrine-induced contraction was 6.3 nmol/l and 66 nmol/l, respectively. |
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