| Identification | Back Directory | [Name]
TALIPEXOLE | [CAS]
101626-70-4 | [Synonyms]
Domin
Talipexol
TALIPEXOLE
Talipexolum
Talipexolum [latin]
Talipexol [spanish]
TALIPEXOLE USP/EP/BP
6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine
6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine
6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
5，6，7，8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4，5-d]azepin-2-amine
4H-Thiazolo[4,5-d]azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propen-1-yl)- | [Molecular Formula]
C10H15N3S | [MDL Number]
MFCD00867565 | [MOL File]
101626-70-4.mol | [Molecular Weight]
209.31 |
| Chemical Properties | Back Directory | [Boiling point ]
364.6±37.0 °C(Predicted) | [density ]
1.167±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
7.22±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
Domin was launched in Japan for Parkinson's disease. The compound is
readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its
antiparkinson activity resides in the fact that talipexole is a selective agonist for
presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most
widely used dopamine angonist. Also it is 70 times more potent than bromocriptine
and has a more rapid onset of action. In addition to its anti-tremor activity there was
a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3
receptor antagonistic activity. Its metabolites have no biological activity, there was
no development of tolerence and its effect could be enhanced by L-dopa. | [Originator]
Boehringer Ingelheim (Germany) | [Definition]
ChEBI: 6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine is an azepine. | [Brand name]
Domin | [storage]
Store at -20°C |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|