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ChemicalBook--->CAS DataBase List--->1015474-32-4

1015474-32-4

1015474-32-4 Structure

1015474-32-4 Structure
IdentificationBack Directory
[Name]

CC-122
[CAS]

1015474-32-4
[Synonyms]

CC-122
CS-2428
Avadomide
CC122;CC 122
CC122 (Avadomide)
Avadomide(CC-122)
AVADOMIDE;CC122;CC 122
Avadomide (Synonyms: CC 122)
3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)piperidine-2,6-dione
3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione
2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-
[Molecular Formula]

C14H14N4O3
[MDL Number]

MFCD29919294
[MOL File]

1015474-32-4.mol
[Molecular Weight]

286.29
Chemical PropertiesBack Directory
[Melting point ]

> 270°C (dec.)
[density ]

1.58±0.1 g/cm3(Predicted)
[storage temp. ]

Hygroscopic, -20°C Freezer, Under inert atmosphere
[solubility ]

DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
[form ]

Solid
[pka]

10.66±0.40(Predicted)
[color ]

Pale Beige
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
Hazard InformationBack Directory
[Description]

3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione has been shown to treat Diffuse large B-cell lymphoma with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon, a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4.
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