| Identification | Back Directory | [Name]
N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide | [CAS]
1011244-68-0 | [Synonyms]
TFAP
CS-2896
COX-1 Inhibitor IV
COX-1 Inhibitor IV(TFAP)
N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide
N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide
Benzamide, N-(5-amino-2-pyridinyl)-4-(trifluoromethyl)- | [Molecular Formula]
C13 H10 F3 N3 O | [MOL File]
1011244-68-0.mol | [Molecular Weight]
281.23 |
| Chemical Properties | Back Directory | [Boiling point ]
360.8±42.0 °C(Predicted) | [density ]
1.425±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMF: 5mg/mL; DMSO: 10mg/mL; Ethanol: 10mg/mL; Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL | [form ]
Off-white solid | [pka]
11.02±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC50 of 0.8 μM. | [Biological Activity]
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a cell-permeable and selective cyclooxygenase-1 (COX-1) inhibitor with IC50 of 0.8 μM. | [in vitro]
TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC 50 of 0.8 μM, while that against COX-2 is over 200 μM. | [target]
| Target | Value | COX-1
(Cell-free assay) | 0.8 μM |
| [IC 50]
COX-1: 0.8 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Kakuta H, et al. Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1840-3. DOI:10.1016/j.bmcl.2010.01.161 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|