| Identification | Back Directory | [Name]
MLN 3897 | [CAS]
1010731-97-1 | [Synonyms]
AVE9897
AVE-9897
MLN 3897
AVE 9897
[1]Benzoxepino[3,4-b]pyridine-7-carboxylic acid, 5-[3-[(4R)-5-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-1-piperidinyl]propylidene]-5,11-dihydro- | [Molecular Formula]
C30H31ClN2O4 | [MOL File]
1010731-97-1.mol | [Molecular Weight]
519.03 |
| Hazard Information | Back Directory | [Description]
MLN-3897, also known as AVE-9897, is a C-C Motif Chemokine Receptor 1 (CCR1) antagonist potentially for the treatment of multiple sclerosis and rheumatoid arthritis. MLN3897 abrogates its effects by inhibiting Akt signaling. Moreover, MM cell-to-OC adhesion was abrogated by MLN3897, thereby inhibiting MM cell survival and proliferation. MLN3897 demonstrates significant impairment of OC formation (by 40%) and function (by 70%), associated with decreased precursor cell multinucleation and down-regulation of c-fos signaling. |
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